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Cham: Springer International Publishing; — Insight into nanoparticle cellular uptake and intracellular targeting. Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy. A review of glycosylated carriers for drug delivery. Baenziger JU, Maynard Y. Human hepatic lectin. Physiochemical properties and specificity. J Biol Chem. Asialoglycoprotein receptor mediated hepatocyte targeting — strategies and applications.

Drug delivery system targeting advanced hepatocellular carcinoma: current and future. Porous lactose-modified chitosan scaffold for liver tissue engineering: influence of galactose moieties on cell attachment and mechanical stability. Int J Polym Sci. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor ASGPR expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv.


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Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells. A new triantennary galactose-targeted PEGylated gene carrier, characterization of its complex with DNA, and transfection of hepatoma cells. Bioconjug Chem. Lactobionic acid-modified dendrimer-entrapped gold nanoparticles for targeted computed tomography imaging of human hepatocellular carcinoma.

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Lactobionic acid and carboxymethyl chitosan functionalized graphene oxide nanocomposites as targeted anticancer drug delivery systems. Carbohydr Polym. Galactosylated fluorescent labeled micelles as a liver targeting drug carrier. Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation. Nanomedicine Lond. Galactose-decorated cross-linked biodegradable poly ethylene glycol -b-poly epsilon-caprolactone block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel.

Ligand-directed reduction-sensitive shell-sheddable biodegradable micelles actively deliver doxorubicin into the nuclei of target cancer cells. Glyco-nanoparticles with sheddable saccharide shells: a unique and potent platform for hepatoma-targeting delivery of anticancer drugs.

Introduction

Galactose-installed photo-crosslinked pH-sensitive degradable micelles for active targeting chemotherapy of hepatocellular carcinoma in mice. Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin. Targeted doxorubicin delivery by chitosan-galactosylated modified polymer microbubbles to hepatocarcinoma cells. Colloids Surf B Biointerfaces.

Critical Reviews™ in Therapeutic Drug Carrier Systems

Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma. Asialoglycoprotein receptor targeted gene delivery using galactosylated polyethylenimine-graft-poly ethylene glycol : in vitro and in vivo studies.

Lactose mediated liver-targeting effect observed by ex vivo imaging technology. Asialoglycoprotein receptor-magnetic dual targeting nanoparticles for delivery of RASSF1A to hepatocellular carcinoma. Sci Rep. Paclitaxel-loaded poly gamma-glutamic acid -poly lactide nanoparticles as a targeted drug delivery system against cultured HepG2 cells. Acta Biomater. Asialoglycoprotein receptor-mediated gene delivery to hepatocytes using galactosylated polymers.

Galactose-based thermosensitive nanogels for targeted drug delivery of iodoazomycin arabinofuranoside IAZA for theranostic management of hypoxic hepatocellular carcinoma. Dependence on fine structural features. Effect of galactose density on asialoglycoprotein receptor-mediated uptake of galactosylated liposomes. Uptake characteristics of galactosylated emulsion by HepG2 hepatoma cells.

Ligand-receptor-mediated drug delivery: an emerging paradigm in cellular drug targeting.

Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: investigating the role played by PEG spacer. Galactosylated polymeric carriers for liver targeting of sorafenib. Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. Cross-linked hyaluronic acid sub-micron particles: in vitro and in vivo biodistribution study in cancer xenograft model.

J Mater Sci. PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo. Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment. Exp Opin Drug Deliv. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy.

Glycosaminoglycan-targeted iron oxide nanoparticles for magnetic resonance imaging of liver carcinoma. Mater Sci Eng C. Hyaluronic acid co-functionalized gold nanoparticle complex for the targeted delivery of metformin in the treatment of liver cancer HepG2 cells.

Nano-Pharmacology and Drug Targeting

Pectin nanoparticle enhances cytotoxicity of methotrexate against HepG2 cells. Drug Deliv. In vitro and in vivo evaluation of pectin-based nanoparticles for hepatocellular carcinoma drug chemotherapy. Mol Pharm. Evidence for receptor-mediated hepatic uptake of pullulan in rats.

Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discov Today. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. Kamen BA, Capdevila A. Receptor-mediated folate accumulation is regulated by the cellular folate content. Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Lett.

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein Sorafenib and triptolide as combination therapy for hepatocellular carcinoma. Asian Pacific J Cancer Prev.


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The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model. Clin Exp Pharm Physiol. The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells. Therapeutic efficacy of improved alpha-fetoprotein promoter-mediated tBid delivered by folate-PEIcyclodextrin nanopolymer vector in hepatocellular carcinoma.